The Corner

Science & Tech

New Developments on the Hydroxychloroquine Front

A woman holds a prescription of hydroxychloroquine, Seattle, Wash., March 31, 2020. (Lindsey Wasson/Reuters)

First: It seems that several major studies, including one in The Lancet suggesting that the drug is actually harmful, were based on rather questionable data. The Guardian has the details: “The US-based company Surgisphere, whose handful of employees appear to include a science fiction writer and an adult-content model, has provided data for multiple studies on Covid-19 co-authored by its chief executive, but has so far failed to adequately explain its data or methodology.” The company has a minimal online presence, and the “get in touch” function on its website doesn’t even work, yet it provided data it claimed to get from “more than a thousand hospitals worldwide.” These revelations follow concerns aired elsewhere that the data seemed fishy.

Second, though, a randomized trial found that the drug didn’t measurably help to prevent COVID-19 when given to individuals who’d been exposed to infected people. From the New York Times:

Conducted in the United States and Canada, this trial was the first to test whether the drug could prevent illness in people who have been exposed to the coronavirus. This type of study, in which patients are picked at random to receive either an experimental treatment or a placebo, is considered the most reliable way to measure the safety and effectiveness of a drug. The participants were health care workers and people who had been exposed at home to ill spouses, partners or parents.

“The take-home message for the general public is that if you’re exposed to someone with Covid-19, hydroxychloroquine is not an effective post-exposure, preventive therapy,” the lead author of the study, Dr. David R. Boulware, from the University of Minnesota, said in an interview.

The drug could still be effective against COVID-19 in other situations, and there are other trials in the works. And there are some weaknesses to the study itself:

Not all the participants could be tested for the virus, because when the study was being conducted, there was still a shortage of test kits.

There was no meaningful difference between the placebo group and those who took the drug. Among those taking hydroxychloroquine, 49 of 414, or 11.8 percent, became ill. In the placebo group, 58 or 407, or 14.3 percent, became ill. Analyzed statistically, the difference between those rates was not significant.

In other words, they couldn’t test everyone to make sure their illnesses were COVID-19, and people who got the drug were about 17 percent less likely to become “ill” — a difference that wasn’t statistically significant because the study was so small. But there’s no denying this is disappointing news.

Most Popular

Education

Destroy the ‘Public’ Education System

‘Public” schools have been a catastrophe for the United States. This certainly isn’t an original assertion, but as we watch thousands of authoritarian brats tearing down the legacies of George Washington and Abraham Lincoln, it’s more apparent than ever. State-run schools have undercut two fundamental ... Read More
Education

Destroy the ‘Public’ Education System

‘Public” schools have been a catastrophe for the United States. This certainly isn’t an original assertion, but as we watch thousands of authoritarian brats tearing down the legacies of George Washington and Abraham Lincoln, it’s more apparent than ever. State-run schools have undercut two fundamental ... Read More
Culture

A Triumph at Mount Rushmore

If nothing else, President Donald Trump’s July Fourth speech at Mount Rushmore clarified the battle lines of our culture war. The New York Times called the speech “dark and divisive,” while an Associated Press headline declared, “Trump pushes racial division.” A Washington Post story said the speech ... Read More
Culture

A Triumph at Mount Rushmore

If nothing else, President Donald Trump’s July Fourth speech at Mount Rushmore clarified the battle lines of our culture war. The New York Times called the speech “dark and divisive,” while an Associated Press headline declared, “Trump pushes racial division.” A Washington Post story said the speech ... Read More
Culture

Why Progressives Wage War on History

Princeton University’s decision to remove the name “Woodrow Wilson” from its School of Public and International Affairs is a big win for progressive activists, and the implications will extend far beyond the campus. It hardly surprises me, in today’s polarizing environment, that my alma mater caved to ... Read More
Culture

Why Progressives Wage War on History

Princeton University’s decision to remove the name “Woodrow Wilson” from its School of Public and International Affairs is a big win for progressive activists, and the implications will extend far beyond the campus. It hardly surprises me, in today’s polarizing environment, that my alma mater caved to ... Read More
U.S.

Bad News about the Virus

On the menu today: an important update about indications that the coronavirus is now more contagious than it used to be, with far-reaching ramifications for how we fight this pandemic; a point on the recent complaints about the Paycheck Protection Program; and a new book for everyone closely following the debate ... Read More
U.S.

Bad News about the Virus

On the menu today: an important update about indications that the coronavirus is now more contagious than it used to be, with far-reaching ramifications for how we fight this pandemic; a point on the recent complaints about the Paycheck Protection Program; and a new book for everyone closely following the debate ... Read More
World

Putin’s Empire Strikes Back

In 1648, at the negotiating tables of Münster and Osnabrück, a panoply of European diplomats signed a document that would lay down the foundations of the modern world order: the Treaty of Westphalia. Naturally, the signatories did not realize the impact of their contribution to history. Far from a pack of ... Read More
World

Putin’s Empire Strikes Back

In 1648, at the negotiating tables of Münster and Osnabrück, a panoply of European diplomats signed a document that would lay down the foundations of the modern world order: the Treaty of Westphalia. Naturally, the signatories did not realize the impact of their contribution to history. Far from a pack of ... Read More