Human Exceptionalism

Adult Stem Cells Used to Prevent Tumors in ESCR

This gets a bit complicated: In mice, scientists used adult stem cells to prevent embryonic stem cells used to treat spinal cord injury from forming tumors. From the story:

Transplanted embryonic stem cells are recognized as a potential treatment for patients suffering from the effects of spinal cord injury (SCI). However, in studies using embryonic stem cells transplanted into SCI laboratory animals, a serious drawback has been the development of tumors following transplantation.

Publishing in the current issue of Cell Transplantation (Vol. 18 No.1), a team of Japanese researchers describe their study that demonstrates a way to eliminate the problem of tumor growth by co-transplanting bone marrow stem cells (BMSCs) along with embryonic stem cells. “Our study results suggest that co-transplanting BMSCs induce undifferentiated embryonic stem cells to differentiate into a neuronal lineage by neurotrophic factor production, resulting in suppression of tumor formation in SCI model mice,” said corresponding author Dr. Masahide Yoshikawa of the Nara Medical University. “…

A control group of mice that only received ES cells developed tumors at the grafted site and their behavioral improvement ceased after three weeks. No tumors developed in the co-transplantation group and behavioral improvement continued over the five-week study. To date, no effective medical therapy has been available for SCI patients. While ES cells have been thought to represent a potential resource for therapy, the hurdle of tumor formation has impeded efforts.

Unmentioned in the article is that adult stem cells in human trials have restored sensation to spinal cord injury patients with both paraplegia and quadriplegia. But never mind, this could move the future of direct ESC therapies forward.

Most Popular

Elections

Trump’s Disgraceful Gambit

The Rudy Giuliani–led press conference at the RNC yesterday was the most outlandish and irresponsible performance ever by a group of lawyers representing a president of the United States. If Giuliani’s charge of a “national conspiracy” to produce fraudulent votes in Democratic cities around the country ... Read More
Elections

Trump’s Disgraceful Gambit

The Rudy Giuliani–led press conference at the RNC yesterday was the most outlandish and irresponsible performance ever by a group of lawyers representing a president of the United States. If Giuliani’s charge of a “national conspiracy” to produce fraudulent votes in Democratic cities around the country ... Read More
Elections

System over Policy, Nation over Faction

One of the more insidious things about President Trump is the way he acts as a kind of gravitational distortion in our political-moral space. His combination of self-serving unscrupulousness and weaponized charisma adds ethical weight to the decisions of more ordinary politicians and pundits. Political ... Read More
Elections

System over Policy, Nation over Faction

One of the more insidious things about President Trump is the way he acts as a kind of gravitational distortion in our political-moral space. His combination of self-serving unscrupulousness and weaponized charisma adds ethical weight to the decisions of more ordinary politicians and pundits. Political ... Read More
Politics & Policy

‘The Dumbest Coup’

Noah Rothman’s excellent piece in Commentary, “The Dumbest of Coups,” deserves to be widely read. I’ve been writing about conspiracy theories for a while now — QAnon, the Flat-Earth gang, etc. — and one of the things you quickly learn about conspiracy theories is that every conspiracy theory is, ... Read More
Politics & Policy

‘The Dumbest Coup’

Noah Rothman’s excellent piece in Commentary, “The Dumbest of Coups,” deserves to be widely read. I’ve been writing about conspiracy theories for a while now — QAnon, the Flat-Earth gang, etc. — and one of the things you quickly learn about conspiracy theories is that every conspiracy theory is, ... Read More
Elections

Election 2020’s Endgame

Today on the menu: States are certifying their votes, and Trump's legal team is in turmoil. The 2020 Election Starts to Wind Down Michigan and Pennsylvania are set to certify their election results today, and Nevada is scheduled to do the same tomorrow. Saturday night, U.S. district judge Matthew W. ... Read More
Elections

Election 2020’s Endgame

Today on the menu: States are certifying their votes, and Trump's legal team is in turmoil. The 2020 Election Starts to Wind Down Michigan and Pennsylvania are set to certify their election results today, and Nevada is scheduled to do the same tomorrow. Saturday night, U.S. district judge Matthew W. ... Read More