News

Health Care

Moderna Vaccine Human Trial Produces COVID-19 Antibodies in All 45 Participants

A scientist works in a lab testing COVID-19 samples at New York City’s health department in New York, N.Y., April 23, 2020. (Brendan McDermid/Reuters)

American biotech firm Moderna announced Monday that its phase-one human trial for a coronavirus vaccine produced COVID-19 antibodies in every one of its participants.

Two vaccine doses of 25 micrograms showed that, by day 43 of the trial, humans developed antibody levels consistent with those who have recovered from coronavirus, the company said. Participants who received 100-microgram doses had antibodies that “significantly exceeded levels” found in recovered patients.

“These interim Phase 1 data, while early, demonstrate that vaccination with mRNA-1273 elicits an immune response of the magnitude caused by natural infection starting with a dose as low as 25 [micrograms],” Tal Zaks, the chief medical officer at Moderna, said in a statement.

The trial also found that the vaccine produced neutralizing antibodies in at least eight participants — four of whom received a 25-microgram dose, while the other four received 100 mcg. When tested against a live virus, Moderna said the levels of neutralizing antibodies were at or above levels seen in blood samples.

“When combined with the success in preventing viral replication in the lungs of a pre-clinical challenge model at a dose that elicited similar levels of neutralizing antibodies, these data substantiate our belief that mRNA-1273 has the potential to prevent COVID-19 disease and advance our ability to select a dose for pivotal trials,” Zaks added.

The news caused Moderna’s stock-price to surge ahead of Monday’s opening bell. Chief Executive Stephane Bancel told the Wall Street Journal that the company aimed to have a “pivotal” phase-three study in July. “We are investing to scale up manufacturing so we can maximize the number of doses we can produce to help protect as many people as we can from SARS-CoV-2,” she stated.

There are currently seven other coronavirus vaccines that have already started human trials, with the Trump administration continuing to orchestrate “Operation Warp Speed,” with the goal of making 300 million doses of a successful vaccine available to Americans by the start of 2021.

Send a tip to the news team at NR.

Most Popular

U.S.

First, Restore Order

Doing evil in the service of a just cause does not change either side of the moral equation: Evil remains evil, and the just cause remains just — neither consideration cancels out the other or transmutes it. With riots and violence convulsing American cities after the horrifying death of George Floyd at the ... Read More
U.S.

First, Restore Order

Doing evil in the service of a just cause does not change either side of the moral equation: Evil remains evil, and the just cause remains just — neither consideration cancels out the other or transmutes it. With riots and violence convulsing American cities after the horrifying death of George Floyd at the ... Read More
Elections

Trump in Trouble

President Trump was disappointed. Bad weather on Wednesday forced a delay in SpaceX's planned launch of the Dragon spacecraft, robbing the president of a prized photo opportunity. He plans to attend the next launch, scheduled for May 30 at 3:22 p.m. EDT, but the spoiled visit to Florida punctuated another week of ... Read More
Elections

Trump in Trouble

President Trump was disappointed. Bad weather on Wednesday forced a delay in SpaceX's planned launch of the Dragon spacecraft, robbing the president of a prized photo opportunity. He plans to attend the next launch, scheduled for May 30 at 3:22 p.m. EDT, but the spoiled visit to Florida punctuated another week of ... Read More

Tired of ‘Winning’ Yet?

I’ve never really thought of Mark Steyn as a Palestinian suicide bomber before. You’ll want some context. Steyn, a wonderful writer and former National Review colleague, was filling in for Rush Limbaugh a few weeks ago, and he made the case for using antitrust law to bully technology platforms such as ... Read More

Tired of ‘Winning’ Yet?

I’ve never really thought of Mark Steyn as a Palestinian suicide bomber before. You’ll want some context. Steyn, a wonderful writer and former National Review colleague, was filling in for Rush Limbaugh a few weeks ago, and he made the case for using antitrust law to bully technology platforms such as ... Read More
Politics & Policy

Is It Revolution?

I knew I was tempting fate a week ago when I said that the coming nomination of Joe Biden and the COVID-19 pandemic had put America’s politics on chill during this election year. Little did I know that days later we’d be making analogies to 1968. The killing of George Floyd by a Minneapolis policeman moved ... Read More
Politics & Policy

Is It Revolution?

I knew I was tempting fate a week ago when I said that the coming nomination of Joe Biden and the COVID-19 pandemic had put America’s politics on chill during this election year. Little did I know that days later we’d be making analogies to 1968. The killing of George Floyd by a Minneapolis policeman moved ... Read More
PC Culture

For Looters, Looting Is Fun

One important thing to realize about looting is that it's usually enjoyable for those engaged in it, who exult in the momentary suspension of any rules. Just a couple of examples from the last couple of days (language ... Read More
PC Culture

For Looters, Looting Is Fun

One important thing to realize about looting is that it's usually enjoyable for those engaged in it, who exult in the momentary suspension of any rules. Just a couple of examples from the last couple of days (language ... Read More