The U.S. Chamber of Commerce has released its second television ad in Pennsylvania, attacking Joe Sestak for supporting “anti-business” policies and for his record of voting with Nancy Pelosi 97 percent of the time.

Sestak has been on the defensive in the Keystone State against Pat Toomey for weeks after a flat-footed response to a critical advertisement by the Emergency Committee for Israel.

While Toomey continues to play up his businessman bona fides (he helped run a restaurant in Allentown in the 1990s) with his “More Jobs, Less Government” mantra, Sestak struggles to differentiate himself from the Democrat establishment he has aligned himself with over the past four years. Playing defense on the Pelosi Question, Sestak trails Toomey by six points in the latest Rasmussen poll.

Few have summed up Sestak’s problem better than Jennifer Rubin at Commentary: “In this year, the Democrats have to run very smart races to survive the GOP wave. So far, Sestak isn’t.”