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Charles Krauthammer said that the exchange on the Trans-Pacific Partnership was the low moment for Hillary Clinton in the first presidential debate with Donald Trump, since it showed her lack of principle:

In fact she did call it “the gold standard.” And this one exchange, this one issue, exemplifies all that’s wrong with the Clinton candidacy. She obviously is not saying the truth. She changed her mind on it, which can happen, but it’s obvious that she changed her mind only because she was being hit by Sanders on this issue, and because Trump was having such success in coming out against trade, and all public opinion has turned against trade.
There’s no candidate on either side, of any stature, who is defending free trade. So she accommodates, she listens, she puts her finger up to feel which way the wind is blowing, and she goes that way. That was her low point.