Some fascinating stuff coming in from readers. Sample:

โ€œJohnโ€”A hole can be drilled through the center of a beam (wood or metal)

without substantially reducing its capacity to bear a load. At the risk of

getting too deep into structural design theory, there exists a neutral axis

that runs through the longitudinal center of a beam. In a typical beam

loading condition, the top of the beam will be in maximum compression and

the bottom will be in maximum tension. As this transition occurs in a

linear fashion through the cross-section of the beam, there is zero stress

at the neutral axis, to comply with the โ€˜lawsโ€™ of statics. Therefore, any

removal of material at or near the neutral axis will not meaningfully affect

the load carrying capacity of the beam. I mention this to you because it

may be quite cumbersome to design all your connections to avoid drilling

through the center of a beam. On the other hand, this could become an

interesting design detail that would distinguish your tree house.โ€

Other readers have warned me that a tree house is every wasp colonyโ€™s

favorite place to build a nest, so when you come back from summer vacation,

check carefully before entering.