Eliot Cohen writes:

At the heart of the problem is not simply the nuclear program. It is the Iranian regime, a regime that has, since 1979, relentlessly waged war against the U.S. and its allies. From Buenos Aires to Herat, from Beirut to Cairo, from Baghdad to, now, Caracas, Iranian agents have done their best to disrupt and kill. Iran is militarily weak, but it is masterful at subversive war, and at the kind of high-tech guerrilla, roadside-bomb and rocket fight that Hezbollah conducted in 2006. American military cemeteries contain the bodies of hundreds, maybe thousands, of American servicemen and servicewomen slain by Iranian technology, Iranian tactics, and in some cases, Iranian operatives. . . .
This is a corrupt, fanatical, ruthless and unprincipled regime—unpopular, to be sure, but willing to do whatever it takes to stay in power. With such a regime, no real negotiation, based on understandings of mutual interest and respect for undertakings is possible.
It is, therefore, in the American interest to break with past policy and actively seek the overthrow of the Islamic Republic. Not by invasion, which this administration would not contemplate and could not execute, but through every instrument of U.S. power, soft more than hard. And if, as is most likely, President Obama presides over the emergence of a nuclear Iran, he had best prepare for storms that will make the squawks of protest against his health-care plans look like the merest showers on a sunny day.