Former ambassador to Luxembourg and leader of the Missouri Republican Party Ann Wagner has announced her intention to run for the RNC chair:

In a video announcement to members of the national committee, Ms. Wagner said the party needed new leadership to prepare for the 2012 presidential campaign, as well as a renewed focus on fund-raising, transparency and accountability.
“We must be efficient, relevant, professional and credible,” Ms. Wagner said. “We must start immediately to erase past debt and to restore the confidence of our donor base. We must have these resources in order to take back the White House and complete the job that was started this year.”

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