National Enquirer (which we can now cite as a reliable news source):

New spy film Edwin A. Salt is undergoing a major sex change. Reportedly, Tom Cruise is out and Angelina Jolie is in. The espionage thriller was to have starred Tom Cruise, says Variety but now is being rewritten as a star vehicle for action mamma Angelina Jolie. The tile character is a CIA agent accused of being a Russian sleeper spy who must elude capture prove her innocence. Sources close to the project say it won’t take that much of a rewrite to change Ed to Edwina – probably a title change. Angie is also in talks to topline Ayn Rand lit classic Atlas Shrugged.